Thermo Fisher Scientific TACC3 Recombinant Rabbit Monoclonal Antibody (SY10-06)
TACC3 단백질을 검출하기 위한 Thermo Fisher의 재조합 토끼 단클론 항체(SY10-06). Western blot, IHC, ICC/IF에 사용 가능하며 높은 특이성과 일관성을 제공. HEK293 발현 시스템 기반으로 생산된 고순도 항체로 연구용에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SY10-06 |
| Immunogen | Synthetic peptide within Human TACC3 aa 40–89 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809340 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
TACC1 is located on the 8p11 chromosomal region, amplified in approximately 15% of breast tumor samples. The short arm of chromosome 8 also contains FGFR1, which shows enhanced expression in most breast cancer tumors.
TACC family members (TACC1, TACC2, TACC3) map closely to FGFR1, FGFR2, and FGFR3 genes on chromosomes 4, 8, and 10, respectively.
Since they are phylogenetically related, TACC and FGFR are proposed to play similar roles in cell growth and differentiation.
TACC1 contains a conserved C-terminal region as in the Drosophila homolog D-TACC, which is necessary for normal spindle function. Mammalian TACC proteins interact with centrosomes and microtubules in a similar manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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