Thermo Fisher Scientific C4BPB Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 17-251 of human C4BPB (NP_0010173641) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:C4BPB,uniProtId:P20851-1,ncbiNodeId:9606,antigenRange:17-251,antigenLength:252,antigenImageFileName:PA5-109469_C4BPB_P20851-1_Rabbit.svg,antigenImageFileNamePDP:PA5-109469_C4BPB_P20851-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.78 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2854880

Product Specific Information

Immunogen sequence: ASDEHCPELP PVDNSIFVAK EVEGQILGTY VCIKGYHLVG KKTLFCNASK EWDNTTTECR LGHCPDPVLV NGEFSSSGPV NVSDKITFMC NDHYILKGSN RSQCLEDHTW APPFPICKSR DCDPPGNPVH GYFEGNNFTL GSTISYYCED RYYLVGVQEQ QCVDGEWSSA LPVCKLIQEA PKPECEKALL AFQESKNLCE AMENFMQQLK ESGMTMEELK YSLELKKAEL KAKLL

Target Information

Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven alpha chains and one beta chain. C4BP functions as a cofactor for C3beta inactivator in the cleavage of C3beta, and accelerates the decay of C4betaC2alpha (C3 convertase) by acting as a cofactor in the cleavage of C4beta by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family, can bind to overlapping C4beta binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurrences of bacterial opsonization and phagocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.