Thermo Fisher Scientific NLRP3 Polyclonal Antibody
Thermo Fisher Scientific의 NLRP3 Polyclonal Antibody는 마우스 NLRP3 단백질을 인식하는 Rabbit IgG 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 50% glycerol 용액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 0.01–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein NLR Family, Pyrin Domain Containing Protein 3 (amino acids 671–1033) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903808 |
Target Information
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, a component of the NALP3 inflammasome complex. This complex acts as an upstream activator of NF-kappaB signaling and regulates inflammation, immune response, and apoptosis. Mutations in this gene are linked to familial cold autoinflammatory syndrome and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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