Thermo Fisher Scientific Caspase 5 Polyclonal Antibody
Caspase-5 단백질을 검출하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CASP5 (Accession P51878), corresponding to amino acid residues S118–R168 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852259 |
Product Specific Information
Antibody detects endogenous levels of total Caspase 5.
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Unlike apoptotic caspases, inflammatory caspases are associated with immune responses to microbial pathogens. Members include caspase-1, -4, -5, and -12. Activation of these caspases leads to cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-5 interacts with caspase-1 as part of the NALP1 inflammasome complex, which triggers cleavage of pro-IL-1β. Expression of caspase-5 is regulated by LPS and IFN-γ.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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