Thermo Fisher Scientific VDAC1 Monoclonal Antibody (4C4)
VDAC1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody(4C4). Western blot과 ELISA에 적합하며, Human 시료에 반응. Affinity chromatography로 정제된 액상 형태로, PBS(pH 7.4)에 보존제 없이 제공. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C4 |
| Immunogen | VDAC1 (AAH08482, 1 a.a. ~100 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAVPPTYADL GKSARDVFTK GYGFGLIKLD LKTKSENGLE FTSSGSANTE TTKVTGSLET KYRWTEYGLT FTEKWNTDNT LGTEITVEDQ LARGLKLTFD
Target Information
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. They are located in the mitochondrial outer membrane and also expressed in the plasma membrane.
At least three different VDAC genes have been identified in vertebrates. VDAC proteins play essential roles in cellular metabolism and the early stages of apoptosis.
VDAC forms a major pathway for metabolite exchange (e.g., ADP/ATP, succinate, citrate) between the cytosol and mitochondria. VDAC1 in the plasma membrane contributes to apoptosis regulation, potentially via its redox activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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