Thermo Fisher Scientific NUMB Monoclonal Antibody (OTI4F3), TrueMAB
NUMB 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체. Western blot과 파라핀 조직 면역조직화학에 적합. 인간 시료 반응성, Mouse IgG2a 아이소타입. 고순도 친화 크로마토그래피 정제, 안정적인 PBS/BSA/glycerol 저장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F3 |
| Immunogen | Full-length human recombinant NUMB protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. It functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domains undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca²⁺ channel (VGCC) inhibitors or by Ca²⁺ chelators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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