Thermo Fisher Scientific beta-2 Adrenergic Receptor Polyclonal Antibody
Human ADRB2를 인식하는 Rabbit Polyclonal 항체로, IHC 및 ICC/IF에 적합합니다. 보존제가 없는 액상 형태이며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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- PA580323
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:300–1:10,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human ADRB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787652 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human ADRB2.
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor (GPCR) superfamily that bind the endogenous catecholamines epinephrine and norepinephrine.
Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family.
Nine receptor subtypes have been identified thus far, including:
- Three alpha-1 AR subtypes (1A/D, 1B, and 1C)
- Three alpha-2 ARs (2A, 2B, and 2C)
- Three beta AR subtypes (1, 2, and 3)
ARs are involved in the onset or maintenance of several disease states, including:
- Hypertension
- Cardiac dysfunction (congestive heart failure, ischemia, arrhythmias)
- Diabetes
- Glaucoma
- Depression
- Impotence
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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