Thermo Fisher Scientific RRAS Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence: LESQRQVPRSE ASAFGASHHV AYFEASAKL
• Highest antigen sequence identity to orthologs: mouse 80%, rat 80%

Target Information

The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signaling pathways control processes such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration.
These GTPases act as molecular switches that control eukaryotic cell function by cycling between GDP-bound inactive and GTP-bound active forms.
Mutations in Ras proto-oncogenes (H-Ras, N-Ras, K-Ras) are found in 20–30% of all human tumors.
K-Ras mutations are frequent in non-small-cell lung, colorectal, and pancreatic carcinomas; H-Ras in bladder, kidney, and thyroid carcinomas; N-Ras in melanoma, hepatocellular carcinoma, and hematologic malignancies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.