Thermo Fisher Scientific RRAS Polyclonal Antibody
RRAS 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 시료에 반응합니다. Immunocytochemistry(ICC/IF)에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human RRAS. Recombinant protein control fragment (Product # RP-107002) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662519 |
Product Specific Information
- Immunogen sequence: LESQRQVPRSE ASAFGASHHV AYFEASAKL
- Highest antigen sequence identity to orthologs: mouse 80%, rat 80%
Target Information
The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signaling pathways control processes such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration.
These GTPases act as molecular switches that control eukaryotic cell function by cycling between GDP-bound inactive and GTP-bound active forms.
Mutations in Ras proto-oncogenes (H-Ras, N-Ras, K-Ras) are found in 20–30% of all human tumors.
K-Ras mutations are frequent in non-small-cell lung, colorectal, and pancreatic carcinomas; H-Ras in bladder, kidney, and thyroid carcinomas; N-Ras in melanoma, hepatocellular carcinoma, and hematologic malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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