Thermo Fisher Scientific BMPR1A Recombinant Rabbit Monoclonal Antibody (002)

Applications

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, and individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse ALK-3/BMPRIA.

Target Information

BMPR1A is a Type I member of the TGF-beta receptor superfamily of transmembrane serine/threonine kinases that phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are closely related to activin receptors ACVR1 and ACVR2. Ligands of these receptors belong to the TGF-beta superfamily. TGF-betas and activins signal through heteromeric complexes of two types of serine/threonine kinase receptors:

• Type I receptors (~50–55 kDa)
• Type II receptors (~70–80 kDa)

Type II receptors bind ligands independently of type I receptors but require them for signaling, whereas type I receptors require type II receptors for ligand binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.