Thermo Fisher Scientific CD204 Polyclonal Antibody
Thermo Fisher Scientific의 CD204 Polyclonal Antibody는 인간 MSR1에 반응하는 토끼 IgG 항체로, WB 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보존됩니다. 대식세포 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MSR1. Recombinant protein control fragment (Product #RP-93669). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789028 |
Product Specific Information
Immunogen sequence:
KWETKNCSVS STNANDITQS LTGKGNDSEE EMRFQEVFME HMSNMEKRIQ HILDMEANLM DTEHFQNFSM TTDQRFNDIL LQLSTLFSSV QGHGNAIDEI SKSLISLNTT LLDLQLNIEN L
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer’s disease, and host defense.
The isoforms type 1 and type 2 are functional receptors and mediate endocytosis of modified low-density lipoproteins (LDLs).
Isoform type 3 does not internalize modified LDL due to altered intracellular processing, remaining trapped within the endoplasmic reticulum. It can inhibit the function of isoforms type 1 and type 2 when co-expressed, suggesting a dominant negative regulatory mechanism.
Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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