Thermo Fisher Scientific TrkB Monoclonal Antibody (10B6C4)
TrkB 단백질을 인식하는 마우스 단클론 항체로, WB, IHC(P), ELISA에 적합합니다. 인간 시료에 반응하며, Protein G 정제 및 PBS 버퍼에 0.05% sodium azide를 포함합니다. 신경계 발달 및 시냅스 기능 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10B6C4 |
| Immunogen | Purified recombinant fragment of human NTRK2 (aa 207–339) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4 °C short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898499 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
NTRK2 (TrkB) belongs to the neurotrophic factor receptor family essential for the development and maintenance of the mammalian nervous system. It acts as a receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway, leading to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Multiple splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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