Thermo Fisher Scientific P-Selectin Monoclonal Antibody (HI62P)
Human P-Selectin(CD62P)을 인식하는 마우스 단클론 항체(HI62P)로, Western Blot 및 유세포분석에 사용 가능. Protein A로 정제된 액상형 항체이며, 1 mg/mL 농도로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HI62P |
| Immunogen | Human platelets |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 15 mM sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1955409 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein and a key regulator of cell rolling. It is stored in the Weibel-Palade bodies of endothelial cells and α-granules of platelets, and rapidly translocates to the cell surface after stimulation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP.
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, playing a critical role in leukocyte-endothelial adhesion. It is a calcium-dependent receptor that binds sialylated Lewis carbohydrate antigens on neutrophils and monocytes.
P-selectin expression is associated with inflammation, atherogenesis, thrombosis, and tissue injury. Clinically, P-selectin is used to distinguish heparin-induced thrombocytopenia with and without thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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