Thermo Fisher Scientific SMCR8 Recombinant Rabbit Monoclonal Antibody (HL1007)
SMCR8 단백질을 특이적으로 인식하는 Thermo Fisher의 재조합 토끼 단일클론 항체. Western blot, IHC, ICC/IF에 사용 가능하며, 인간, 마우스, 랫트 시료에 반응합니다. Protein A로 정제된 액상 형태로, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1007 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SMCR8 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898189 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
SMCR8 is a component of the C9orf72-SMCR8 complex, which has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. Within the complex, C9orf72 and SMCR8 act as catalytic subunits promoting the exchange of GDP to GTP, activating RAB8A and RAB39B, and facilitating autophagosome maturation.
The complex also negatively regulates autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its kinase activity. SMCR8 further modulates mTORC1 signaling by promoting phosphorylation of its substrates. In the nucleus, SMCR8 associates with chromatin and negatively regulates expression of ULK1 and WIPI2 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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