Thermo Fisher Scientific HOXA13 Recombinant Rabbit Monoclonal Antibody (ARC1636)
HOXA13 단백질을 인식하는 재조합 토끼 단클론 항체로 Western Blot 및 ELISA에 적합. 인간, 마우스, 랫트 반응성. HEK293 세포에서 발현된 IgG 형태의 항체로 고순도 친화 크로마토그래피 정제. -20°C에서 안정적 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1636 |
| Immunogen | Synthetic peptide corresponding to amino acids 250–350 of human HOXA13 (UniProt ID: P31271) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.67 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849709 |
Product Specific Information
Immunogen sequence:
LDMPVVPGLG GPGESRHEPL GLPMESYQPW ALPNGWNGQM YCPKEQAQPP HLWKSTLPDV VSHPSDASSY RRGRKKRVPY TKVQLKELER EYATNKFITK D
Target Information
HoxA13 and HoxD13 also bind to other BMP and TGF-beta/Activin-regulated Smad proteins including Smad1 and Smad2, but not Smad4.
In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues.
Analysis of HoxA13 expression reveals a pattern of localization overlapping with sites of reduced Bmp2 and Bmp7 expression in HoxA13 mutant limbs.
HoxA13 regulates Bmp2 and Bmp7 expression, providing a link between HoxA13, its target genes, and the specific developmental processes affected by loss of HoxA13 function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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