Thermo Fisher Scientific HOXA13 Recombinant Rabbit Monoclonal Antibody (ARC1636)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC1636

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HOXA13 (P31271) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HOXA13,uniProtId:P31271-1,ncbiNodeId:9606,antigenRange:250-350,antigenLength:388,antigenImageFileName:MA5-35809_HOXA13_P31271-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35809_HOXA13_P31271-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.67 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849709

Product Specific Information

Immunogen sequence: LDMPVVPGLG GPGESRHEPL GLPMESYQPW ALPNGWNGQM YCPKEQAQPP HLWKSTLPDV VSHPSDASSY RRGRKKRVPY TKVQLKELER EYATNKFITK D

Target Information

HoxA13 and HoxD13 also bind to other BMP and TGF-beta/Activin-regulated Smad proteins including Smad1 and Smad2, but not Smad4. In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues. Analysis of HoxA13 expression reveals a pattern of localization overlapping with sites of reduced Bmp2 and Bmp7 expression in HoxA13 mutant limbs. HoxA13 regulates Bmp2 and Bmp7 expression, providing a link between HoxA13, its target genes and the specific developmental processes affected by loss of HoxA13 function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.