Thermo Fisher Scientific Bcl-B Polyclonal Antibody
Bcl-B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 고순도 액상 항체로, 장기 보관 시 -20°C에서 안정적. 인간 시료 반응성.
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- PA522190
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- pk
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Thermo Fisher Scientific Bcl-B Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | View publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 60–153 of BCL2L10 (Uniprot ID: Q9HD36) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.32 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11155374 |
Product Specific Information
- Recommended positive controls: Jurkat, Raji, NCI-H929
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene belongs to the BCL-2 family, which regulates apoptosis through hetero- or homodimer formation. It contains conserved BH4, BH1, and BH2 domains and interacts with BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression suppresses apoptosis by preventing cytochrome C release and caspase-3 activation. The mouse homolog interacts with Apaf1 and Caspase 9, indicating involvement in APAF1 and CASPASE 9-related apoptotic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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