Thermo Fisher Scientific TSC2 Polyclonal Antibody
Rabbit에서 유래한 TSC2 단클론 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 인간 Tuberous Sclerosis 2 단백질의 C-말단 영역(1750–1807)을 면역원으로 사용하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 4°C에서 보관하며, 종양 억제 관련 연구에 활용됩니다.
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Thermo Fisher Scientific TSC2 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:5,000–1:15,000
- Immunoprecipitation (IP): 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1750 and the C-terminus (residue 1807) of Human Tuberous Sclerosis 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2)
TSC2 is implicated as a tumor suppressor and may function in vesicular transport, cell growth arrest, and transcription regulation mediated by steroid receptors.
It associates with hamartin (TSC1) in a cytosolic complex, possibly acting as a chaperone. Phosphorylation of tuberin on Ser939 and Thr1462 regulates its interaction with hamartin via the PI3K/Akt pathway.
TSC2 stimulates the intrinsic GTPase activity of RAP1A and RAB5, suggesting a role in growth regulation. Mutations in TSC2 are linked to diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma.
Alternative splicing results in three different isoforms of TSC2.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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