Thermo Fisher Scientific Torc2 Polyclonal Antibody
Torc2 단백항체로 Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능. 인간 CRTC2 단백질에 특이적이며 Rabbit Polyclonal 형식. 항원 친화 크로마토그래피로 정제된 액상 형태로 안정적. 연구용으로 에너지 대사 관련 유전자 발현 연구에 적합.
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- PA583015
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CRTC2. Recombinant protein control fragment (Product #RP-94355) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2790171 |
Product Specific Information
Immunogen sequence:
SPSASLVLDP PGFSEGPGFL GGEGPMGGPQ DPHTFNHQNL THCSRHGSGP NIILTGDSSP GFSKEIAAAL AGVPGFEVSA AGLELGLGL
Target Information
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB) 2), and the related protein CRTC1 are potent CREB coactivators exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions.
Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP.
CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism, while CRTC1 is essential for energy balance and fertility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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