Thermo Fisher Scientific XBP1 Polyclonal Antibody, MaxPab
인간 XBP1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western Blot에 최적화되어 있으며, 액상 형태로 제공. PBS 완충액에 보관하며, -20°C에서 안정적. 연구용으로만 사용 가능.
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Thermo Fisher Scientific XBP1 Polyclonal Antibody, MaxPab
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | XBP1 (NP_005071.2, 1–261 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MVVVAAAPNP ADGTPKVLLL SGQPASAAGA PAGQALPLMV PAQRGASPEA ASGGLPQARK RQRLTHLSPE EKALRRKLKN RVAAQTARDR KKARMSELEQ QVVDLEEENQ KLLLENQLLR EKTHGLVVEN QELRQRLGMD ALVAEEEAEA KGNEVRPVAG SAESAALRLR APLQQVQAQL SPLQNISPWI LAVLTLQIQS LISCWAFWTT WTQSCSSNAL PQSLPAWRSS QRSTQKDPVP YQPPFLCQWG RHQPSWKPLM N
Target Information
XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which also acts as a cellular transcription factor interacting with viral enhancer regions such as those of T cell leukemia virus type 1.
Upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), XBP1 mRNA undergoes unconventional splicing mediated by IRE1, producing the active isoform XBP1(S). The unspliced isoform, XBP1(U), functions as a negative feedback regulator of XBP1(S). A pseudogene of XBP1 is localized to chromosome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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