Thermo Fisher Scientific Angiopoietin 2 Recombinant Rabbit Monoclonal Antibody (1F10)
인간 Angiopoietin 2를 인식하는 재조합 토끼 단클론 항체로, IHC(P) 및 ELISA에 적합합니다. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현되었습니다. 액상 형태로 제공되며, -20°C 이하에서 안정적으로 보관 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1F10 |
| Immunogen | A synthesized peptide derived from human Angiopoietin 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092744 |
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2 but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis.
The signaling interactions of ANG-1, ANG-2, and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acid residues and is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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