Thermo Fisher Scientific GABRA1 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1342)
Recombinant alpaca VHH monoclonal antibody against human GABRA1. Suitable for ELISA and SPR assays. Expressed in CHO cells and purified via metal-chelate chromatography. Provided in PBS without preservative, ideal for neuroscience research.
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Applications
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Surface Plasmon Resonance (SPR)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1342 |
| Immunogen | Recombinant Human GABRA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing membrane hyperpolarization through the opening of a Cl⁻ channel associated with the GABAA receptor (GABAA-R) subtype.
GABAA-Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABAA-R is a multimeric subunit complex composed of multiple alpha, beta, and gamma subunits and their splice variants. Expression of alpha and beta subunits alone yields GABA-sensitive receptors, but coexpression with a gamma subunit is required for benzodiazepine modulation.
Different alpha subunits may mediate distinct benzodiazepine effects, and phosphorylation of beta subunits modulates GABAA-R function.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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