
Thermo Fisher Scientific TCR beta Monoclonal Antibody (H57-597), PE
마우스 TCR 베타 체인을 인식하는 단클론 항체로 Flow Cytometry에 적합합니다. PE 형광 표지로 565/576 nm에서 검출 가능하며, Protein G 정제 및 PBS/BSA 버퍼에 보관됩니다. 4°C에서 저장하며 연구용으로만 사용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 0.2–1.0 µg/1×10⁶ cells
- Publications: View 1 publication
Miscellaneous PubMed (Misc)
- Publications: View 10 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H57-597 |
| Immunogen | Affinity-purified DO-11.10 TCR |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539043 |
Additional Formats
Target Information
T cell receptors (TCR) enable discrimination between foreign and self-peptides presented by MHC class II molecules, essential for adaptive immune responses. TCR recognition of self-peptides has been linked to autoimmune diseases, while mutant self-peptides are associated with tumors. Engagement of TCRs by bacterial superantigens can lead to toxic shock syndrome. Autoantibodies to V beta segments of TCRs have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially modulating TH1-mediated inflammatory responses.
Most human T cells express the TCR alpha-beta along with CD4 or CD8 molecules. A small subset lacks both (double negative, DN) and may be increased in autoimmune or immunodeficiency disorders. Gamma-delta T cells, mainly found in epithelial tissues, exhibit reduced TCR diversity and distinct antigen recognition, with subsets showing antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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