Thermo Fisher Scientific TCR beta Monoclonal Antibody (H57-597), PE

Applications

Flow Cytometry (Flow)

• Tested Dilution: 0.2–1.0 µg/1×10⁶ cells
• Publications: View 1 publication

Miscellaneous PubMed (Misc)

• Publications: View 10 publications

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• FITC
• Request custom conjugation

Target Information

T cell receptors (TCR) enable discrimination between foreign and self-peptides presented by MHC class II molecules, essential for adaptive immune responses. TCR recognition of self-peptides has been linked to autoimmune diseases, while mutant self-peptides are associated with tumors. Engagement of TCRs by bacterial superantigens can lead to toxic shock syndrome. Autoantibodies to V beta segments of TCRs have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially modulating TH1-mediated inflammatory responses.

Most human T cells express the TCR alpha-beta along with CD4 or CD8 molecules. A small subset lacks both (double negative, DN) and may be increased in autoimmune or immunodeficiency disorders. Gamma-delta T cells, mainly found in epithelial tissues, exhibit reduced TCR diversity and distinct antigen recognition, with subsets showing antitumor and immunoregulatory activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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