Thermo Fisher Scientific PCBP2 Recombinant Rabbit Monoclonal Antibody (JE65-05)

Applications

Western Blot (WB)

• Tested Dilution: 1:500
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:400–1:500
• Publications: References

Product Specifications

Target Information

The protein encoded by this gene is multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains involved in RNA binding. Together with PCBP-1, this protein acts as a translational coactivator of poliovirus RNA via specific interaction with stem-loop IV of the IRES, promoting RNA replication by binding to its 5′-terminal cloverleaf structure. It is also implicated in translational control of 15-lipoxygenase mRNA, HPV type 16 L2 mRNA, and hepatitis A virus RNA. Furthermore, it contributes to formation of an alpha-globin mRNP complex associated with mRNA stability. PCBP2 and PCBP-1 have paralogous genes (PCBP3, PCBP4) arising from gene duplication events, and two processed pseudogenes (PCBP2P1, PCBP2P2). Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: MA5-44699_PCBP2_Q15366-1_Rabbit_PDP.jpeg)