Thermo Fisher Scientific NTHL1 Recombinant Rabbit Monoclonal Antibody (JE65-02)
Rabbit 유래 재조합 단클론 항체로 인간 NTHL1 단백질을 특이적으로 인식합니다. Western blot과 IHC(P) 실험에 최적화되어 있으며, 고순도 Protein A 정제 방식으로 제조되었습니다. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE65-02 |
| Immunogen | Recombinant protein within human NTH1 aa 1–150/312 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931158 |
Target Information
Oxygen radicals damage chromosomal DNA causing cell death and mutations. Although much focus has been on the repair of 8-oxo-G, many other oxidatively damaged DNA sites are created by free-radical attack. The human NTH1 repair protein acts on a wide range of these damaged sites. As a homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. It has broad substrate specificity, including various ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removing oxidative base lesions in mitochondrial DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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