Thermo Fisher Scientific Phospho-Crystallin (A-Beta) (Ser59) Polyclonal Antibody
Phospho-Crystallin (A-Beta) (Ser59) 단백질을 인식하는 Rabbit Polyclonal 항체. WB 및 IHC(P) 실험에 적합하며, Bovine, Human, Mouse, Rat에 반응. 항원 친화 크로마토그래피로 정제, 0.5 mg/mL 농도의 액상 형태로 제공.
- 카탈로그번호
- 630-400ABBOMAX
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide SFLRAP-(pS)-WFD containing the phosphorylation site Serine 59 of human Crystallin (A-beta) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Eye tissue
- Cellular location: Cytoplasmic
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to maintain the proper refractive index.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
Alpha-crystallin is composed of two primary gene products, alpha-A and alpha-B, and accounts for about 40% of total lens protein. It also functions as a molecular chaperone, preventing aggregation that may lead to cataract formation.
Phosphorylation of alpha-crystallin is thought to occur in response to cellular stress and may regulate structural stability and protein maintenance. Alpha-B crystallin has been associated with Alexander’s disease, where it accumulates in brain cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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