Thermo Fisher Scientific NUMBL Polyclonal Antibody
Human NUMBL 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:200~1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 신경발생 관련 연구에 적합. 4°C 단기, -20°C 장기 보관 권장.
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- PA563564
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- pk
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NUMBL. Recombinant protein control fragment (Product # RP-98382) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644889 |
Product Specific Information
Immunogen sequence:
NELPSTLQRR TDFQVKGTVP EMEPPGAGDS DSINALCTQI SSSFASAGAP
Highest antigen sequence identity to orthologs:
- Mouse: 96%
- Rat: 94%
Target Information
NUMBL plays a role in neurogenesis and is required throughout embryonic neurogenesis to maintain neural progenitor (radial glial) cells. It allows daughter cells to choose progenitor over neuronal cell fate and is also required postnatally in subventricular zone (SVZ) neurogenesis for neuroblast survival and ependymal wall integrity.
Acts as a negative regulator of the NF-kappa-B signaling pathway by preventing MAP3K7IP2 interaction with polyubiquitin chains of TRAF6 and RIPK1, and by promoting Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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