Thermo Fisher Scientific PHD3 Polyclonal Antibody
인간 및 생쥐 PHD3 단백질을 검출하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 세포 내 산소 감지 및 HIF 단백질 연구에 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human EGLN3 (Accession Q9H6Z9), corresponding to amino acid residues E37–G87 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2849814 |
Product Specific Information
Antibody detects endogenous levels of total PHD3.
Target Information
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates specific proline residues in the oxygen-dependent degradation (ODD) domains of HIF1A and HIF2A, primarily at the CODD site. Hydroxylated HIFs are targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, hydroxylation is reduced, allowing HIFs to translocate to the nucleus and activate hypoxia-inducible genes.
EGLN3 (PHD3) also hydroxylates PKM, ADRB2, and TELO2, influencing glycolysis, apoptosis, and DNA damage response pathways. Plays a key role in regulating cardiomyocyte and neuronal apoptosis, and hypoxic inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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