Thermo Fisher Scientific OPA1 Monoclonal Antibody (1C10)

Applications

• ELISA (ELISA)

Tested Dilution

• 1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
NHCNLCRRGF YYYQRHFVDS ELECNDVVLF WRIQRMLAIT ANTLRQQLTN TEVRRLEKNV KEVLEDFAED GEKKIKLLTG KRVQLAEDLK KVREIQEKLD AFIEALHQEK

Target Information

OPA1 is a dynamin-related GTPase that is critical for the maintenance of mitochondrial morphology and mtDNA. The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a dominant trait that causes reduced visual clarity and sometimes blindness. The disease usually begins in childhood and increases in severity throughout life. This phenotype is attributed to degeneration of optic nerve fibers. OPA1 dysfunction is also implicated in schizophrenia-related nerve degeneration, apoptosis regulation, and mitochondrial network maintenance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.