Thermo Fisher Scientific OPA1 Monoclonal Antibody (1C10)
OPA1 단백질을 인식하는 Mouse monoclonal antibody (Clone 1C10). 인간 시료에 반응하며 ELISA에 적합. Affinity chromatography로 정제된 액상 항체로, 보존제가 포함되지 않음. -20°C에서 보관하며 연구용으로만 사용 가능.
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Applications
- ELISA (ELISA)
Tested Dilution
- 1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C10 |
| Immunogen | OPA1 (NP_056375, 851 a.a. ~ 960 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
NHCNLCRRGF YYYQRHFVDS ELECNDVVLF WRIQRMLAIT ANTLRQQLTN TEVRRLEKNV KEVLEDFAED GEKKIKLLTG KRVQLAEDLK KVREIQEKLD AFIEALHQEK
Target Information
OPA1 is a dynamin-related GTPase that is critical for the maintenance of mitochondrial morphology and mtDNA. The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a dominant trait that causes reduced visual clarity and sometimes blindness. The disease usually begins in childhood and increases in severity throughout life. This phenotype is attributed to degeneration of optic nerve fibers. OPA1 dysfunction is also implicated in schizophrenia-related nerve degeneration, apoptosis regulation, and mitochondrial network maintenance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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