Thermo Fisher Scientific PNPase Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total PNPase.

Target Information

PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondrial) is an RNA-binding protein implicated in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3′-to-5′ direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3′ overhang double-stranded RNA with a 3′-to-5′ directionality in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. PNPT1 also plays roles in cytoplasmic RNA import, mitochondrial morphogenesis and respiration, regulation of electron transport chain expression, stability of specific mature miRNAs in melanoma cells, and RNA surveillance. Mutations in this gene can result in combined oxidative phosphorylation deficiency 13 (COXPD13) and autosomal recessive deafness 70 (DFNB70).

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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