Thermo Fisher Scientific LARP1 Polyclonal Antibody
LARP1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, IP에 사용 가능. mTORC1 경로 관련 단백질 연구에 적합하며, 4°C 보관 및 1년 안정성 보장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 275 and 325 of human La ribonucleoprotein domain family, member 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
LARP1 is an RNA-binding protein that regulates translation of specific mRNA species downstream of the mTORC1 complex, in response to growth signals and nutrient availability.
It interacts with both the 3′ poly-A tails of mRNAs and the 7-methylguanosine cap structure of mRNAs containing a 5′ terminal oligopyrimidine (5′TOP) motif, which includes mRNAs encoding ribosomal proteins and translation machinery components.
This interaction represses translation by preventing EIF4G1 binding. Upon mTORC1 activation, LARP1 is phosphorylated and dissociates from the 5′ UTR of mRNAs.
It associates with ribosomes and enhances translation of 5′TOP motif-containing mRNAs, promoting protein synthesis, cell growth, and proliferation.
LARP1 also stabilizes these mRNAs, preventing apoptosis.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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