Thermo Fisher Scientific LARP1 Polyclonal Antibody
LARP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 사용 가능. 액상 형태, 4°C 보관, 0.2 mg/mL 농도. mTORC1 경로 관련 RNA 결합 단백질 연구에 적합.
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Thermo Fisher Scientific LARP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 575 and 625 of human La ribonucleoprotein domain family, member 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
LARP1 is an RNA-binding protein that regulates translation of specific target mRNAs downstream of the mTORC1 complex in response to growth signals and nutrient availability. It interacts with both the 3′ poly-A tails and the 7-methylguanosine cap structure of mRNAs containing a 5′ terminal oligopyrimidine (5′TOP) motif, which are typically mRNAs encoding ribosomal proteins and components of the translation machinery.
Under normal nutrient conditions, LARP1 associates with actively translating ribosomes and promotes protein synthesis, cell growth, and proliferation. It stabilizes mRNAs with a 5′TOP motif, helping to prevent apoptosis.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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