Thermo Fisher Scientific CD45RB Monoclonal Antibody (PTPRC, 1147)
인간 CD45RB 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합합니다. Protein A/G로 정제된 액상형 제품이며, 보존제가 없는 PBS 용액에 1 mg/mL 농도로 제공됩니다. 면역세포 신호전달 및 생존 연구에 활용됩니다.
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Thermo Fisher Scientific CD45RB Monoclonal Antibody (PTPRC, 1147)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PTPRC, 1147 |
| Immunogen | Human recombinant full-length CD45 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
CD45RB is a receptor-type protein tyrosine phosphatase, part of the CD45 glycoprotein family.
CD45 plays a crucial role in lymphocyte development and antigen signaling, acting as a regulator of Src-family kinases. It promotes cell survival through integrin-mediated signal transduction and is involved in DNA fragmentation during apoptosis.
CD45 isoforms differ in extracellular domains but share identical transmembrane and cytoplasmic regions. Their expression varies by cell type and physiological state.
CD45RB is expressed in microglia and inflammatory cells and is essential for immunoreceptor signaling and hematopoietic lineage cell function, excluding mature red cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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