Thermo Fisher Scientific FGR Recombinant Rabbit Monoclonal Antibody (13H37L5)
FGR 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 ICC/IF에 사용 가능. Expi293 시스템에서 발현되며, 높은 특이성과 일관된 품질을 제공. 단기 보관은 4°C, 장기 보관은 -20°C에서 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Insect |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 13H37L5 |
| Immunogen | Protein corresponding to human FGR [aa1–aa76] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2734808 |
Product Specific Information
This antibody is predicted to react with Monkey, Pig, and Horse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, followed by screening to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the extensive rabbit immune repertoire
Target Information
FGR is a SRC-related kinase expressed in hematopoietic cells. It functions within multiple signaling pathways, including integrin and chemokine/cytokine receptor pathways. The protein features:
- N-terminal myristylation and palmitoylation sites
- PTK, SH2, and SH3 domains for protein-protein interactions
FGR localizes to plasma membrane ruffles and acts as a negative regulator of cell migration and adhesion via the beta-2 integrin signaling pathway. Epstein-Barr virus infection can lead to overexpression of this protein.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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