Thermo Fisher Scientific MAGE1 Polyclonal Antibody
MAGE1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(PFA) 실험에 적합합니다. 인간 및 생쥐 시료에서 반응하며, 암 관련 항원 연구 및 종양 면역치료 타깃 연구에 유용합니다. 1 mg/mL 농도의 액상형 제품으로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAGEA1 (Accession P43355), corresponding to amino acid residues G24–R74 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900171 |
Product Specific Information
Antibody detects endogenous levels of total MAGE1.
Target Information
Human malignant neoplasms carry rejection antigens recognized by autologous, tumor-directed, cytolytic CD8+ T lymphocyte clones (CTL). The MAGE family of genes encodes an important group of such antigens, identified as melanoma-associated antigens (MAAs).
MAGE-1 is expressed in a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) but not in normal tissues. Therefore, the encoded antigen may serve as a marker for early detection and as a target for cancer immunotherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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