Thermo Fisher Scientific PNPase Monoclonal Antibody (3H5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondrial) is an RNA-binding protein involved in multiple RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides in the 3′-to-5′ direction and is a component of the mitochondrial degradosome (mtEXO) complex that degrades double-stranded RNA with 3′ overhangs in an ATP-dependent manner. PNPT1 is essential for proper processing and polyadenylation of mitochondrial mRNAs. It also functions as a cytoplasmic RNA import factor, contributing to mitochondrial morphogenesis, respiration, and regulation of electron transport chain expression. Additionally, it influences the stability of specific mature miRNAs in melanoma cells and participates in RNA surveillance. Mutations in this gene can cause combined oxidative phosphorylation deficiency 13 (COXPD13) and autosomal recessive deafness 70 (DFNB70).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.