Thermo Fisher Scientific HLA-B Polyclonal Antibody
Human HLA-B 단백질을 인식하는 염소 유래 Polyclonal 항체. Western blot과 IHC(파라핀 절편)에서 검증됨. 0.5 mg/mL 농도의 액상 형태로 제공되며, TBS(pH 7.3, 0.5% BSA) 버퍼에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DRNTQIYKAQAQT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933900 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is membrane-anchored and plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen.
These molecules are expressed in nearly all cells. The heavy chain (~45 kDa) gene contains 8 exons:
- Exon 1 encodes the leader peptide
- Exons 2 and 3 encode the α1 and α2 domains (peptide-binding)
- Exon 4 encodes the α3 domain
- Exon 5 encodes the transmembrane region
- Exons 6 and 7 encode the cytoplasmic tail
Polymorphisms in exons 2 and 3 determine peptide-binding specificity. Typing of these polymorphisms is routinely performed for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
HLA and MHC antibodies are essential in Immunopeptidomics, facilitating neoantigen identification and characterization using HPLC-tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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