Thermo Fisher Scientific EphB1 (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• The reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and freeze at -20°C.
• Avoid repeated freeze-thaw cycles.
• Centrifuge antibody preparations before use (10,000 × g, 5 min).

Peptide sequence: (C)RSQTNTA RIDGLR
Homology: Rat and human amino acid residues are identical.

Target Information

EPHB1 is a receptor tyrosine kinase belonging to the ephrin receptor family. Members of the Eph family play key roles in biological processes such as:

• Nervous system development
• Angiogenesis
• Neural synapse formation and maturation

EphB1 and related family members are type I membrane-spanning proteins containing immunoglobulin, fibronectin type III, and cysteine-rich subdomains in the ectodomain, and a cytoplasmic tyrosine kinase domain upstream of a carboxy-terminal sterile alpha motif (SAM) domain. EphB family proteins bind ephrins of the B class, which are transmembrane ligands capable of bidirectional signaling.

EphB1 is primarily expressed in developing neural structures and vascular epithelium of the kidney and other tissues. Upon binding ephrin B1, EphB1 regulates cell attachment and assembly. These proteins are implicated in neuronal and vascular cell targeting.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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