Thermo Fisher Scientific TRK fused gene Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TFG. Recombinant protein control fragment (Product #RP-92560). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRK fused gene,uniProtId:Q92734-1,ncbiNodeId:9606,antigenRange:308-396,antigenLength:400,antigenImageFileName:PA5-53996_TRK_fused_gene_Q92734-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53996_TRK_fused_gene_Q92734-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648412

Product Specific Information

Immunogen sequence: PQQLPAQPPQ QYQASNYPAQ TYTAQTSQPT NYTVAPASQP GMAPSQPGAY QPRPGFTSLP GSTMTPPPSG PNPYARNRPP FGQGYTQPG

Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.

Target Information

TFG protein, a recently identified novel protein, is a human homolog of mouse TFG protein. It contains an N-terminal coiled-coil structure, a SPYGQ-rich region followed by octicosapeptide repeats. Research shows that TFG can modulate SHP-1 activity and is a novel member of the NF-kB pathway. The physiological functions of this protein remain largely elusive, but TFG is thought to function by associating with other proteins, including TANK and NEMO. TFG was first identified as a partner of NTRK1 and is involved in generating the thyroid TRK-T3 oncogene, as well as oncogenic rearrangements with ALK in anaplastic lymphoma and NOR1 in mixoid chondrosarcoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.