Thermo Fisher Scientific Arginase 1 Polyclonal Antibody
Arginase 1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, Western blot, IHC, ICC, Flow Cytometry 등에 사용 가능. 인간, 마우스, 돼지, 랫드 반응성. 액상 형태로 -20°C 보관. 연구용 전용 제품.
- 카탈로그번호
- PA518392
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.01–0.03 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | – |
| Flow Cytometry (Flow) | 10 µg/mL | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Published Species | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (CFGLAREGNHKPID) corresponding to the C-terminus amino acids of ARG1 (aa 303–316) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983554 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts. By degrading arginine, Arginase 1 reduces nitric oxide production by depriving NO synthase of its substrate.
In humans and mice, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. Expression in human blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a). It may also be expressed in myeloid cells infiltrating tumors and is typically found in hepatocellular carcinomas.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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