Thermo Fisher Scientific Arginase 1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Predicted to react with bovine, canine, mouse, porcine, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 64,000.

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of protein degradation byproducts. By degrading arginine, Arginase 1 reduces nitric oxide production by depriving NO synthase of its substrate.
In humans and mice, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. Expression in human blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a). It may also be expressed in myeloid cells infiltrating tumors and is typically found in hepatocellular carcinomas.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.