Thermo Fisher Scientific TAB1 Polyclonal Antibody
TAB1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, 인간·마우스·랫트 반응성. IHC, ICC/IF, ELISA 등 다양한 응용 가능. Protein A 정제, 1 mg/mL 농도, 안정적인 액상 형태로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human MAP3K7IP1/TAB1, amino acids 351–450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which mediates intracellular signaling pathways induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while part of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that TAB1 functions as a mediator between TGF beta receptors and TAK1. TAB1 also interacts with MAPK14/p38alpha, providing an alternative activation pathway contributing to MAPK14 responses to various stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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