Thermo Fisher Scientific ACK1 Polyclonal Antibody
ACK1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 사용 가능. 인간, 생쥐 및 비인간 영장류 시료에 반응. Affinity chromatography로 정제되었으며 PBS/glycerol buffer에 보관. 종양 연구 및 세포 신호전달 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNK2 (Accession Q07912), corresponding to amino acid residues L258–S308 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853918 |
Product Specific Information
This antibody detects endogenous levels of total ACK1.
Target Information
TNK2 (ACK) (activated Cdc42-associated kinase) is a non-receptor tyrosine kinase that signals downstream of Cdc42. TNK2 is involved in tumorigenesis and metastasis, particularly in prostate cancer. It acts as a downstream effector of CDC42, mediating CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 may contribute to synaptic function, brain development, and tumor progression by activating AKT1 and regulating AR, WWOX, and AXL receptor levels. It confers metastatic properties on cancer cells by regulating tumor suppressors and pro-survival factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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