Thermo Fisher Scientific BCL9L Polyclonal Antibody
Human BCL9L 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 최적화됨. 합성 펩타이드(M1-T45)를 면역원으로 사용. 고순도 Affinity chromatography 정제, PBS/glycerol buffer에 보존. 연구용으로만 사용 가능.
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- PA5105738
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL9L (Accession Q86UU0), corresponding to amino acid residues M1–T45 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853921 |
Product Specific Information
Antibody detects endogenous levels of total BCL9L.
Target Information
Bcl9L, a homolog of Bcl9, was identified through bioinformatics screening. It is expressed in fetal brain, adult lung, eye, and prostate, as well as in several tumor types including pancreatic and prostate cancers.
Bcl9L interacts with beta-catenin, a key factor in the Wnt signaling pathway, and is required for enhanced beta-catenin–TCF-mediated transcription in colorectal tumor cells, possibly by facilitating beta-catenin nuclear translocation.
Studies indicate that Bcl9L expression correlates with high nuclear grade cancer phenotype and ErbB2/HER-2 expression in breast cancers, suggesting broader oncogenic activity.
Additionally, Bcl9L is critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas, associated with tumor invasion, metastasis, and therapy resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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