Thermo Fisher Scientific GUK1 Monoclonal Antibody (OTI1D7), TrueMAB
Thermo Fisher Scientific의 GUK1 단클론 항체(OTI1D7)는 인간 Guanylate kinase 단백질을 인식하며, WB, IHC(P), Flow Cytometry에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 안정적인 PBS/BSA/glycerol 버퍼에 보관됩니다.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D7 |
| Immunogen | Full-length human recombinant protein of human GUK1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Guanylate kinase (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast), and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.
Proteins containing one or more copies of the DHR domain, an SH3 domain, as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologs). These include:
- Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1)
- Mammalian tight junction protein Zo-1
- Mammalian synaptic proteins interacting with NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1, SAP102)
- Vertebrate 55 kD erythrocyte membrane protein (p55)
- C. elegans protein lin-2
- Rat protein CASK
- Human proteins DLG2 and DLG3
There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However, these proteins retain the residues known, in GK, to be involved in the binding of MP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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