Thermo Fisher Scientific PSMF1 Polyclonal Antibody
Rabbit polyclonal antibody against human PSMF1 (PI31) for WB and IP applications. Recognizes residues 221–271 of human proteasome activator subunit 1. Predicted cross-reactivity with mouse, rat, bovine, and orangutan. Supplied as 1 mg/mL liquid, stored...
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Applications
Western Blot (WB)
- Tested dilution: 1:1,000–1:5,000
Immunoprecipitation (IP)
- Tested dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 221–271 of Human Proteasome Activator Subunit 1 (PI31, PSMF1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4 °C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, and Orangutan
Target Information
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes: a 20S core and a 19S regulator.
The 20S core consists of four rings of 28 non-identical subunits (two rings of seven α subunits and two rings of seven β subunits).
The 19S regulator includes a base (six ATPase subunits and two non-ATPase subunits) and a lid (up to ten non-ATPase subunits).
Proteasomes are abundant in eukaryotic cells and function in ATP/ubiquitin-dependent peptide cleavage via a non-lysosomal pathway.
The immunoproteasome plays a key role in processing class I MHC peptides.
The PSMF1 gene encodes a protein that inhibits proteasome activation by the 11S and 19S regulators. Alternative transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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