Thermo Fisher Scientific EFHD2 Polyclonal Antibody
EFHD2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 사용 가능. Human 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관되며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human EFHD2. Recombinant protein control fragment (Product # RP-98470) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640923 |
Product Specific Information
- Immunogen sequence: TDELATKLSR RLQMEGEGGG ETPEQPGLN
- Highest antigen sequence identity:
- Mouse: 86%
- Rat: 83%
Target Information
EFHD2 (also known as Swiprosin-1 or SWS1) is an EF-hand and coiled-coil-containing adaptor protein involved in lymphocyte physiology.
It is highly expressed in CD8+ T cells and immature B cells, providing a membrane scaffold required for Syk-, SLP-65-, and PLC-γ2-dependent B-cell receptor (BCR)-induced calcium flux.
EFHD2 may regulate BCR-induced immature and primary B-cell apoptosis and control spontaneous apoptosis through regulation of BCL2L1 abundance.
It also acts as a negative regulator of the canonical NF-κB-activating branch.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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