Thermo Fisher Scientific ITGA4 Polyclonal Antibody
ITGA4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Human, Mouse, Rat 시료에 반응하며 Western Blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)를 보장합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human ITGA4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803636 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
Integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. The alpha4 chain associates with either beta1 or beta7 chains.
It has been demonstrated that the ligand-binding sites of both integrin α4β1 and α4β7 are located on the alpha4 chain. These ligands include MadCAM, VCAM, and fibronectin. MadCAM is the principal ligand for integrin α4β7.
Recent studies show that HIV-1 envelope can mimic MadCAM by binding to and signaling through integrin α4β7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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