Thermo Fisher Scientific MLL1 Polyclonal Antibody
MLL1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, IP, ChIP 등 다양한 응용에 적합합니다. Human 반응성, 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
| ChIP assay (ChIP) | See datasheet |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 2725 and 2775 of human myeloid/lymphoid or mixed-lineage leukemia 1 (KMT2A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
KMT2A is a histone methyltransferase essential for early development and hematopoiesis. It is the catalytic subunit of the MLL1/MLL complex, which mediates methylation of Lys-4 of histone H3 (H3K4me) and acetylation of Lys-16 of histone H4 (H4K16ac). Within the complex, KMT2A specifically catalyzes H3K4me, an epigenetic marker for transcriptional activation. It shows weak methyltransferase activity alone and requires other complex components for full activity. KMT2A is involved in transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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