Thermo Fisher Scientific MLL1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MLL1 (KMT2A), suitable for WB, IP, and ChIP. Recognizes region 2725–2775 of MLL1. Supplied as unconjugated liquid (1 mg/mL), stored at 4°C. Predicted cross-reactivity with mouse.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
| ChIP assay (ChIP) | See datasheet |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 2725 and 2775 of human myeloid/lymphoid or mixed-lineage leukemia 1 (MLL1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
KMT2A is a histone methyltransferase essential for early development and hematopoiesis. It acts as the catalytic subunit of the MLL1/MLL complex, mediating methylation of Lys-4 of histone H3 (H3K4me) and acetylation of Lys-16 of histone H4 (H4K16ac). Within the complex, KMT2A specifically catalyzes H3K4me, a marker of epigenetic transcriptional activation. It has weak methyltransferase activity alone and requires other complex components for full activity. KMT2A shows no activity toward histone H3 phosphorylated on Thr-3, less toward H3 dimethylated on Arg-8 or Lys-9, and higher activity toward H3 acetylated on Lys-9. It is required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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