Thermo Fisher Scientific ASCL1 Polyclonal Antibody
ASCL1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 신경계 발달 관련 단백질 연구에 활용되며, 항원 친화 크로마토그래피로 정제되었습니다. -20°C 보관, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the center region of the Mouse MASH1/ASCL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902404 |
Target Information
ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor required for early nervous system development. It is expressed in fetal brain and is essential for proper development and survival of autonomic neurons. ASCL1 interaction with MEF-2A may regulate expression of genes critical for neuronal circuit formation in the central nervous system. High ASCL1 expression in neuroendocrine tumors, such as medullary thyroid cancer and small cell lung cancer, makes it a useful marker for cancers with neuroendocrine features. The ASCL1 gene maps to human chromosome 12 and contains a trinucleotide repeat region, making it a candidate locus for inherited disease.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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