Thermo Fisher Scientific ABCG5 Polyclonal Antibody
Human ABCG5 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF에 0.25–2 µg/mL 농도로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 기반 버퍼에 보관. ABC 수송체 연구용으로 적합.
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Thermo Fisher Scientific ABCG5 Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.25–2 µg/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ABCG5 (Product #RP-91210) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2637542 |
Product Specific Information
Immunogen sequence:
IHQPRSELFQ LFDKIAILSF GELIFCGTPA EMLDFFNDCG YPCPEHSNPF DFYMDLTSVD TQSKEREIET SKRVQMIESA YKKSAICHKT LKNIERMKHL KTLPMVPFKT KDSPGVFSKL GVLL
Sequence identity:
- Mouse: 81%
- Rat: 81%
Target Information
The ABCG5 gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. These proteins transport various molecules across cellular membranes and are classified into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
ABCG5 belongs to the White subfamily and functions as a half-transporter that limits intestinal absorption and promotes biliary excretion of sterols. It is expressed specifically in the liver, colon, and intestine.
This gene is tandemly arrayed on chromosome 2 with ABCG8 in a head-to-head orientation. Mutations may lead to sterol accumulation and atherosclerosis, as observed in sitosterolemia patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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