Thermo Fisher Scientific CD163 Monoclonal Antibody (OTI1D5), TrueMAB
인간 CD163 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF 분석에 적합합니다. 1 mg/mL 농도의 액상 형태이며, PBS/BSA/glycerol 버퍼에 보관됩니다. 면역세포 표지 및 염증 관련 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D5 |
| Immunogen | Full-length human recombinant CD163 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein belonging to the scavenger receptor cysteine-rich superfamily. It serves as a receptor for the hemoglobin-haptoglobin complex, protecting tissues from oxidative damage and facilitating iron recycling through endocytosis and heme breakdown.
CD163 is expressed on human monocytes and macrophages, especially during the late phase of inflammation. It is found on all circulating monocytes and most tissue macrophages, excluding certain lymphoid follicle cells and Langerhans cells. Expression is upregulated by IL-10, IL-6, and dexamethasone, while LPS and PMA induce shedding of CD163 into plasma or supernatant.
CD163 binds hemoglobin/haptoglobin complexes in a calcium- and pH-dependent manner, with higher affinity for multimeric haptoglobin (HP1F phenotype). It also triggers intracellular signaling cascades involving tyrosine kinase-dependent calcium mobilization, inositol triphosphate production, and secretion of IL6 and CSF1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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